Masri M S
Adv Exp Med Biol. 1984;177:115-46. doi: 10.1007/978-1-4684-4790-3_5.
Aspects of work on aflatoxin mainly from the author's studies are discussed, emphasizing procedures, strategies and insights related to protection against aflatoxin carcinogenesis in man due to transmission in the food chain. Five lines of defense are discussed. First, is the interfacing of the farm animal as a biologic filter between contaminated crop (feed) and human food derived from animal products. Second, is chemical detoxification of meals with ammonia and of contaminated milk by ultraviolet light. Third is prevention of mold growth and aflatoxin elaboration with ammonium carbonate for potential application during storage and drying of agricultural products. Fourth, is the development of ultrasensitive analytical methods for aflatoxins with structural proof of identity. And, fifth are natural defenses related to the role of hydroxylation of mammalian metabolism in detoxification, especially the pathway to aflatoxin Q1, a major detoxifying mechanism in primates, and the epoxidation pathway and its relation to prevention of aflatoxin residue transmission into edible tissues.
本文主要基于作者的研究探讨黄曲霉毒素相关工作的各个方面，重点强调了与通过食物链传播预防人类黄曲霉毒素致癌作用相关的程序、策略和见解。文中讨论了五道防线。首先，农场动物作为生物过滤器，介于受污染的作物（饲料）和来自动物产品的人类食物之间。其次，用氨对饲料进行化学解毒，并用紫外线对受污染的牛奶进行解毒。第三，在农产品储存和干燥过程中，使用碳酸铵预防霉菌生长和黄曲霉毒素生成。第四，开发具有结构鉴定证明的黄曲霉毒素超灵敏分析方法。第五，是与哺乳动物代谢羟基化在解毒中的作用相关的天然防御机制，特别是通往黄曲霉毒素Q1的途径，这是灵长类动物的主要解毒机制，以及环氧化途径及其与预防黄曲霉毒素残留传递到可食用组织的关系。
