Krainess F E, Knapp W J
J Biomed Mater Res. 1978 Mar;12(2):241-6. doi: 10.1002/jbm.820120209.
Rods of dense alumina ceramic were aged in Ringer's solution for time periods up to 12 weeks, with half of the rods being aged while mechanically stressed. Pyrex-type glass rods were similarly tested for comparison purposes. No reduction in flexural strength was observed in dense alumina rods after aging, providing no permeation of the solution into the ceramic occurred. However, a marked reduction in flexural strength was experienced by alumina rods, nominally dense and nonporous, into which some permeation of the saline solution was observed after aging; the largest reduction in strength occurred in such rods aged while mechanically stressed. The results indicate the importance and advantage of using densely sintered alumina ceramics as implants for optimum structural performance over an extended time period.
致密氧化铝陶瓷棒在林格氏溶液中老化长达12周，其中一半的棒在机械应力作用下老化。为作比较，对派热克斯型玻璃棒进行了类似测试。如果溶液没有渗入陶瓷，致密氧化铝棒老化后其抗弯强度没有降低。然而，对于名义上致密且无孔的氧化铝棒，老化后观察到有一些盐溶液渗入其中，其抗弯强度显著降低；在机械应力作用下老化的此类棒强度降低幅度最大。结果表明，使用致密烧结氧化铝陶瓷作为植入物以在较长时间内实现最佳结构性能具有重要意义和优势。
