Hitzhusen J C, Hickler R B, Alpert J S, Doherty P W
Am J Cardiol. 1984 Nov 1;54(8):1082-6. doi: 10.1016/s0002-9149(84)80148-4.
To determine the effect of age on cardiovascular performance, 39 healthy elderly men and women, 70 to 83 years old, underwent treadmill thallium-201 exercise perfusion imaging and radionuclide equilibrium angiography at rest and during supine bicycle exercise. Five volunteers who had a positive exercise thallium test response were excluded from the study. Radionuclide left ventricular ejection fraction, regional wall abnormalities, relative cardiac output, stroke volume, end-diastolic volume and end-systolic volume were measured. Seventy-four percent of the subjects maintained or increased their ejection fraction with exercise. With peak exercise, mean end-diastolic volume did not change, end-systolic volume decreased and cardiac output and stroke volume increased. Moreover, in 35% of the subjects, minor regional wall motion abnormalities developed during exercise. There was no significant difference in the response of men and women with regard to these variables. However, more women than men had difficulty performing bicycle ergometry because they had never bicycled before. Subjects who walked daily performed the exercise tests with less anxiety and with a smaller increase in heart rate and systolic blood pressure.
为了确定年龄对心血管功能的影响，39名年龄在70至83岁之间的健康老年男性和女性，在静息状态以及仰卧位自行车运动期间，接受了跑步机铊-201运动灌注成像和放射性核素平衡血管造影检查。5名运动铊试验反应呈阳性的志愿者被排除在研究之外。测量了放射性核素左心室射血分数、局部室壁异常、相对心输出量、每搏输出量、舒张末期容积和收缩末期容积。74%的受试者在运动时维持或提高了他们的射血分数。在运动高峰时，平均舒张末期容积没有变化，收缩末期容积减小，心输出量和每搏输出量增加。此外，35%的受试者在运动期间出现了轻微的局部室壁运动异常。在这些变量方面，男性和女性的反应没有显著差异。然而，由于从未骑过自行车，更多女性比男性在进行自行车测力计测试时遇到困难。每天步行的受试者在进行运动测试时焦虑程度较低，心率和收缩压的升高幅度较小。
