甲基丙烯酸甲酯：小鼠吸入其蒸汽的致畸性和胎儿毒性研究。

Methylmethacrylate: A study of teratogenicity and fetal toxocity of the vapor in the mouse.

作者信息

McLaughlin R E, Reger S I, Barkalow J A, Allen M S, Dafazio C A

出版信息

J Bone Joint Surg Am. 1978 Apr;60(3):355-8.

Abstract

To determine possible deleterious effects of methylmethacrylate vapor on mouse gestation, pregnant mice were exposed to average vapor concentrations of 1330 parts per million for two hours twice daily during Day 6 through Day 15 of pregnancy. A slight increase in the average weight of the fetuses of the exposed mothers were demonstrated but no other evidence of fetal toxicity or teratologic effects was found. During three total hip replacements, the concentration of methylmethacrylate in operating-room air never rose above 280 parts per million.

摘要

为了确定甲基丙烯酸甲酯蒸汽对小鼠妊娠可能产生的有害影响，在妊娠第6天至第15天期间，将怀孕小鼠每天两次暴露于平均浓度为百万分之1330的蒸汽中，每次两小时。结果显示，暴露组母鼠所产胎儿的平均体重略有增加，但未发现其他胎儿毒性或致畸作用的证据。在3次全髋关节置换手术中，手术室空气中甲基丙烯酸甲酯的浓度从未超过百万分之280。