Haywood J R, Williams S F, Ball N A
Am J Physiol. 1984 Nov;247(5 Pt 2):H797-803. doi: 10.1152/ajpheart.1984.247.5.H797.
The early and chronic stages of one-kidney, figure-8 renal-wrap hypertension were studied during low or normal dietary sodium intake in rats. The renal-wrap procedure caused a significant elevation in arterial pressure at 3 and 28 days postwrap with normal sodium diet. Sodium-depleted rats did not experience an increased arterial pressure following renal wrapping. Blockade of angiotensin II receptors with [Sar1-Ala8]angiotensin II caused a greater decrease in arterial pressure in the sodium-depleted, renal-wrapped animals compared with sham-operated rats. In sodium-replete rats, angiotensin receptor blockade did not lower arterial pressure. Total ganglionic blockade decreased arterial pressure significantly more in the wrapped animals than in the sodium-replete sham-operated rats and the wrapped or sham-wrapped, sodium-deplete animals. Thus the early and chronic phases of normal sodium, one-kidney, figure-8 renal hypertension are supported by an increased sympathetic nervous system function. These observations suggest that sodium is necessary for the development of one-kidney, figure-8 renal-wrap hypertension and that the presence of sodium in the diet permits a functional activation of the sympathetic nervous system in response to the renal-wrap procedure.
在低钠或正常钠饮食摄入的大鼠中，研究了单肾“8”字形肾包绕高血压的早期和慢性阶段。采用正常钠饮食时，肾包绕手术后3天和28天动脉血压显著升高。钠缺乏的大鼠肾包绕后未出现动脉血压升高。与假手术大鼠相比，用[Sar1-Ala8]血管紧张素II阻断血管紧张素II受体，钠缺乏的肾包绕动物的动脉血压下降幅度更大。在钠充足的大鼠中，血管紧张素受体阻断并未降低动脉血压。完全神经节阻断使包绕动物的动脉血压下降幅度明显大于钠充足的假手术大鼠以及包绕或假包绕的钠缺乏动物。因此，正常钠摄入、单肾“8”字形肾高血压的早期和慢性阶段是由交感神经系统功能增强所维持的。这些观察结果表明，钠对于单肾“8”字形肾包绕高血压的发生发展是必需的，并且饮食中钠的存在允许交感神经系统在肾包绕手术后发生功能性激活。
