Smeby L C, Charlton B, Schindhelm K
Am J Physiol. 1984 Nov;247(5 Pt 2):R816-26. doi: 10.1152/ajpregu.1984.247.5.R816.
Selective removal of approximately 60% of the plasma immunoglobulin G (IgG) mass in conscious rabbits was studied and compared with similar procedures combined with intravenous saline infusions equal to 7.5% body weight. Plasma concentrations of 125I-IgG and endogenous IgG were employed in model analysis to examine if saline infusions could be used to shift IgG from extra- to intravascular pool, thereby making more protein available for removal by extracorporeal plasma treatment. After IgG removal, the fractional metabolic clearance and the extra- to intravascular transfer coefficient were 40-50% lower than before IgG removal, and model simulations indicated that this may be caused by IgG binding. Saline infusion resulted in 40% more IgG mass in plasma 24 h after treatment compared with procedures without saline. Model analysis indicated that the increased IgG mass in plasma after saline procedures could be explained by a three- to fourfold increase in lymphatic clearance. Crystalloid infusions may be a method to increase the efficacy of repeated plasma exchange treatment.
研究了在清醒兔体内选择性去除约60%的血浆免疫球蛋白G（IgG）量，并将其与结合静脉输注等于7.5%体重的生理盐水的类似程序进行比较。在模型分析中采用125I-IgG和内源性IgG的血浆浓度，以检查生理盐水输注是否可用于使IgG从血管外池转移至血管内池，从而使更多蛋白质可通过体外血浆处理去除。去除IgG后，分数代谢清除率和血管外至血管内转移系数比去除IgG前低40 - 50%，模型模拟表明这可能是由IgG结合所致。与未输注生理盐水的程序相比，输注生理盐水导致治疗后24小时血浆中IgG量增加40%。模型分析表明，生理盐水程序后血浆中IgG量增加可通过淋巴清除率增加三至四倍来解释。晶体液输注可能是一种提高重复血浆置换治疗效果的方法。
