Homeostatic capability of rate-sensitive feedback system: mathematical model.

We have predicted the mathematical model of rate-sensitive feedback control system and have investigated its homeostatic capability by using computer simulations. The results are summarized as follows. By installing a cyclic enzyme system as feedback control element, we could assume the rate-sensitive feedback system at molecular level. This type of feedback had realistic constant-value control capability for external perturbations. This feedback system was more effective for the exclusion of perturbation than was the concentration-sensitive feedback. A large-loop feedback was more stable for perturbation than was short-loop feedback. In sequential feedback system, every key enzyme sensitive to feedback control had to vary the activity at same time for the system to keep homeostasis.