Okamoto M, Hayashi K
Am J Physiol. 1984 Nov;247(5 Pt 2):R927-31. doi: 10.1152/ajpregu.1984.247.5.R927.
We have predicted the mathematical model of rate-sensitive feedback control system and have investigated its homeostatic capability by using computer simulations. The results are summarized as follows. By installing a cyclic enzyme system as feedback control element, we could assume the rate-sensitive feedback system at molecular level. This type of feedback had realistic constant-value control capability for external perturbations. This feedback system was more effective for the exclusion of perturbation than was the concentration-sensitive feedback. A large-loop feedback was more stable for perturbation than was short-loop feedback. In sequential feedback system, every key enzyme sensitive to feedback control had to vary the activity at same time for the system to keep homeostasis.
我们预测了速率敏感反馈控制系统的数学模型，并通过计算机模拟研究了其稳态调节能力。结果总结如下。通过安装一个循环酶系统作为反馈控制元件，我们可以在分子水平上假设速率敏感反馈系统。这种类型的反馈对外部干扰具有实际的恒定值控制能力。与浓度敏感反馈相比，这种反馈系统在排除干扰方面更有效。大环反馈比短环反馈对干扰更稳定。在顺序反馈系统中，每个对反馈控制敏感的关键酶必须同时改变活性，系统才能保持稳态。
