Okamoto M, Hayashi K
J Theor Biol. 1984 Jun 21;108(4):529-37. doi: 10.1016/s0022-5193(84)80078-8.
The frequency conversion mechanism in enzymatic feedback systems which can keep the system's natural frequency against oscillating perturbations has been investigated with computer simulations. The results indicate that the feedback system, including time-delay element, has the property that the resulting period of the sustained oscillation is an integral multiple of the system's natural period related to frequency entrainment by relaxation oscillators, and the interaction of this system and oscillating inputs could be represented by the theoretical equation proposed for the synchronization of two interacting oscillating systems.
通过计算机模拟研究了酶反馈系统中的频率转换机制，该机制可使系统的固有频率抵御振荡扰动。结果表明，包括时滞元件的反馈系统具有这样的特性：持续振荡的产生周期是与弛豫振荡器的频率夹带相关的系统固有周期的整数倍，并且该系统与振荡输入的相互作用可以用为两个相互作用的振荡系统的同步所提出的理论方程来表示。
