Ishihara O, Yamaguchi Y, Matsuishi T, Yano E, Nakamura Y, Tateishi J, Yamashita F
Brain Dev. 1984;6(4):401-6. doi: 10.1016/s0387-7604(84)80116-3.
A 5-year-old Japanese boy was admitted to our hospital because of progressive visual disturbance and quadriplegia. Computed tomography (CT) revealed multiple low density areas in the cerebral white matter, and intravenous injection of contrast medium resulted in ring enhancement around these areas. Exploratory aspiration of one of the low density areas gave a xanthochromic, viscous fluid. Pathologic examination of the drained fluid demonstrated small pieces of brain tissue with necrotizing lesions surrounded by demyelinating areas. The patient has been followed up for 3 years with corticosteroid treatment, and marked improvement has been achieved both in neurological examination and CT findings. From these clinicopathological findings an acute form of multiple sclerosis (MS) in childhood was suspected.
一名5岁日本男孩因进行性视力障碍和四肢瘫痪入住我院。计算机断层扫描（CT）显示脑白质内有多个低密度区，静脉注射造影剂后这些区域周围出现环形强化。对其中一个低密度区进行穿刺抽吸，抽出了黄色、粘稠的液体。对抽出液进行病理检查发现小块脑组织有坏死性病变，周围有脱髓鞘区域。该患者接受皮质类固醇治疗随访3年，神经检查和CT表现均有明显改善。根据这些临床病理表现，怀疑为儿童急性型多发性硬化症（MS）。
