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Fluorometric measurement of tin-protoporphyrin in biological samples.

作者信息

Simionatto C S, Anderson K E, Sassa S, Drummond G S, Kappas A

出版信息

Anal Biochem. 1984 Aug 15;141(1):213-9. doi: 10.1016/0003-2697(84)90448-2.

DOI:10.1016/0003-2697(84)90448-2
PMID:6496929
Abstract

Sn-protoporphyrin is a potent competitive inhibitor of heme oxygenase, can suppress neonatal and other forms of hyperbilirubinemia in laboratory animals, and represents a potential new approach to the treatment of neonatal jaundice in humans. In order to study the disposition of Sn-protoporphyrin in vivo we have developed a sensitive fluorometric method for the quantitation of this metalloporphyrin in biological samples. The method is sensitive to concentrations as low as 0.01 nmol/ml, and is specific for Sn-protoporphyrin even in the presence of other porphyrins such as protoporphyrin.

摘要

相似文献

1
Fluorometric measurement of tin-protoporphyrin in biological samples.
Anal Biochem. 1984 Aug 15;141(1):213-9. doi: 10.1016/0003-2697(84)90448-2.
2
Tissue distribution and disposition of tin-protoporphyrin, a potent competitive inhibitor of heme oxygenase.锡原卟啉的组织分布与处置，血红素加氧酶的一种强效竞争性抑制剂
J Pharmacol Exp Ther. 1984 Feb;228(2):327-33.
3
Studies on the mechanism of Sn-protoporphyrin suppression of hyperbilirubinemia. Inhibition of heme oxidation and bilirubin production.锡原卟啉抑制高胆红素血症机制的研究。血红素氧化及胆红素生成的抑制作用。
J Clin Invest. 1985 Feb;75(2):513-21. doi: 10.1172/JCI111727.
4
Sn-protoporphyrin inhibition of fetal and neonatal brain heme oxygenase. Transplacental passage of the metalloporphyrin and prenatal suppression of hyperbilirubinemia in the newborn animal.锡原卟啉对胎儿及新生儿脑血红素加氧酶的抑制作用。金属卟啉的胎盘转运及新生动物高胆红素血症的产前抑制。
J Clin Invest. 1986 Mar;77(3):971-6. doi: 10.1172/JCI112398.
5
Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation.锡原卟啉IX预防新生儿高胆红素血症，锡原卟啉IX是血红素氧化的一种有效竞争性抑制剂。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6466-70. doi: 10.1073/pnas.78.10.6466.
6
Sn-protoporphyrin rapidly and markedly enhances the heme saturation of hepatic tryptophan pyrrolase. Evidence that this synthetic metalloporphyrin increases the functional content of heme in the liver.锡原卟啉能迅速且显著地提高肝脏色氨酸吡咯酶的血红素饱和度。有证据表明这种合成金属卟啉可增加肝脏中血红素的功能含量。
J Clin Invest. 1985 Jan;75(1):302-5. doi: 10.1172/JCI111689.
7
Disposition of tin-protoporphyrin and suppression of hyperbilirubinemia in humans.锡原卟啉在人体内的代谢及高胆红素血症的抑制作用
Clin Pharmacol Ther. 1986 May;39(5):510-20. doi: 10.1038/clpt.1986.88.
8
Dual control mechanism for heme oxygenase: tin(IV)-protoporphyrin potently inhibits enzyme activity while markedly increasing content of enzyme protein in liver.血红素加氧酶的双重调控机制：四价锡-原卟啉能有效抑制酶活性，同时显著增加肝脏中酶蛋白的含量。
Proc Natl Acad Sci U S A. 1987 Apr;84(8):2464-8. doi: 10.1073/pnas.84.8.2464.
9
Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism.将锡原卟啉的C2和C4乙烯基还原以形成锡中卟啉，可显著增强金属卟啉在体内抑制血红素分解代谢的能力。
Arch Biochem Biophys. 1987 May 15;255(1):64-74. doi: 10.1016/0003-9861(87)90294-3.
10
The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin.当锡原卟啉竞争性抑制血红素加氧酶时，肝脏会将大量血红素排泄到胆汁中。
Proc Natl Acad Sci U S A. 1985 Feb;82(3):896-900. doi: 10.1073/pnas.82.3.896.

引用本文的文献

1
Sn-protoporphyrin suppresses chemically induced experimental hepatic porphyria. Potential clinical implications.锡原卟啉抑制化学诱导的实验性肝卟啉症。潜在的临床意义。
J Clin Invest. 1985 Dec;76(6):2436-9. doi: 10.1172/JCI112259.
2
The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin.当锡原卟啉竞争性抑制血红素加氧酶时，肝脏会将大量血红素排泄到胆汁中。
Proc Natl Acad Sci U S A. 1985 Feb;82(3):896-900. doi: 10.1073/pnas.82.3.896.
3
Long-term administration of massive doses of Sn-protoporphyrin in anemic mutant mice (sphha/sphha).
在贫血突变小鼠（sphha/sphha）中长期给予大剂量的锡原卟啉。
J Exp Med. 1985 Sep 1;162(3):864-76. doi: 10.1084/jem.162.3.864.
4
Studies on the mechanism of Sn-protoporphyrin suppression of hyperbilirubinemia. Inhibition of heme oxidation and bilirubin production.锡原卟啉抑制高胆红素血症机制的研究。血红素氧化及胆红素生成的抑制作用。
J Clin Invest. 1985 Feb;75(2):513-21. doi: 10.1172/JCI111727.
5
Sn-protoporphyrin inhibition of fetal and neonatal brain heme oxygenase. Transplacental passage of the metalloporphyrin and prenatal suppression of hyperbilirubinemia in the newborn animal.锡原卟啉对胎儿及新生儿脑血红素加氧酶的抑制作用。金属卟啉的胎盘转运及新生动物高胆红素血症的产前抑制。
J Clin Invest. 1986 Mar;77(3):971-6. doi: 10.1172/JCI112398.