Giamarellou H, Tympanidis K, Bitos N A, Leonidas E, Daikos G K
Andrologia. 1984 Sep-Oct;16(5):417-22. doi: 10.1111/j.1439-0272.1984.tb00388.x.
Long term treatment of chronic prostatitis with antimicrobials and their influence on semen quality and infertility were studied in 30 men with mean age of 36.7 +/- 6 years. The infection was symptomatic only in 50% of the patients with abnormal prostatic physical findings in 66.7%. Cardinal findings in the spermatogram were leukocytosis in 100% and oligoasthenozoospermia in 66.5% of the patients. E. coli and Staphylococci presented the most commonly isolated bacteria in prostatic secretion cultures. Various treatment schedules, including mostly co-trimoxazole, doxycycline and erythromycin, were given alternatively for 6-8 months. Symptoms were cured or improved in 79.7%, with elimination or improvement of abnormal physical findings in 85%, while the isolated pathogens were eradicated in all. Spermatograms were normalized or improved in 70% of the patients, while among them 9 impregnated their wives and in 2 of them twice. It is concluded that male infertility in the presence of semen leukocytosis and oligoasthenozoospermia should be investigated for underlying chronic prostatitis, while whenever proved, long term treatment with the proper antimicrobials not only cures or improves chronic prostatitis, but subsequently cures or improves male infertility.
对30名平均年龄为36.7±6岁的男性进行了研究，观察了使用抗菌药物对慢性前列腺炎的长期治疗及其对精液质量和不育症的影响。在66.7%前列腺体格检查异常的患者中，仅50%有感染症状。精液检查的主要结果是，100%的患者有白细胞增多，66.5%的患者有少弱精子症。大肠杆菌和葡萄球菌是前列腺分泌培养物中最常分离出的细菌。采用了多种治疗方案，主要包括复方新诺明、强力霉素和红霉素，交替使用6 - 8个月。79.7%的患者症状治愈或改善，85%的患者异常体格检查结果消除或改善，所有患者的分离病原体均被根除。70%的患者精液检查恢复正常或改善，其中9名患者使妻子受孕，2名患者使妻子受孕两次。结论是，对于存在精液白细胞增多和少弱精子症的男性不育症患者，应调查是否存在潜在的慢性前列腺炎，一旦确诊，使用适当的抗菌药物进行长期治疗不仅能治愈或改善慢性前列腺炎，随后还能治愈或改善男性不育症。
