Schwartz A B, Klausner S C, Yee S, Turchyn M
Arch Intern Med. 1984 Nov;144(11):2260-1.
It has become appreciated that drug levels of procainamide hydrochloride needed to suppress inducible ventricular tachycardia by programmed ventricular stimulation exceed the previously published therapeutic range. Cerebellar ataxia developed acutely in a patient receiving high-dose procainamide. This was associated with a marked increase in the serum drug level. Resolution occurred within three days after drug therapy was discontinued.
现已认识到，通过程控心室刺激抑制可诱发的室性心动过速所需的盐酸普鲁卡因胺药物水平超过了先前公布的治疗范围。一名接受高剂量普鲁卡因胺治疗的患者急性出现小脑共济失调。这与血清药物水平的显著升高有关。在停药后三天内症状消退。
