Job J C, Joab N, Toublanc J E, Canlorbe P
Arch Fr Pediatr. 1984 Aug-Sep;41(7):477-82.
The authors report the results of treatment with human growth hormone (hGH) (for 3 1/2 years to 11 3/4 years, mean: 5 years 4 months) in 34 children presenting with complete growth hormone deficiency and an average growth failure reaching 3.9 standard deviations (SD). Treatment was discontinued, after spontaneous or induced puberty, when bone age reached or was beyond 15 years in boys, and 13 years in girls. A partial correction was obtained in almost all cases. However, average height remained at -2.4 SD with respect to age and -1.75 with respect to bone age, reaching normal limits in only half of the patients. School and professional performances were not appreciably different from those which are observed in normal adolescents. Although the acceptance of the diagnosis and therapy was not always good, the medical support associated with the supervision of the treatment seems to have had a favourable psychological effect.
作者报告了34例完全性生长激素缺乏且平均生长落后达3.9个标准差（SD）的儿童接受人生长激素（hGH）治疗（3年半至11年3/4年，平均：5年4个月）的结果。在自然青春期或诱导青春期后，当男孩骨龄达到或超过15岁、女孩骨龄达到或超过13岁时停止治疗。几乎所有病例均获得部分改善。然而，平均身高相对于年龄仍处于-2.4 SD，相对于骨龄处于-1.75 SD，仅一半患者达到正常范围。学业和职业表现与正常青少年相比无明显差异。尽管对诊断和治疗的接受度并非总是良好，但与治疗监督相关的医疗支持似乎产生了积极的心理效应。
