Miyoshi M, Ogawa K, Shingu K, Omagari N
Arch Histol Jpn. 1984 Aug;47(3):259-69. doi: 10.1679/aohc.47.259.
Renal cysts in the cortex of the monkey kidney were observed by scanning and transmission electron microscopy, in an attempt to determine the three-dimensional structures of the epithelial cells in these cysts. The cysts were composed of a thin wall which limited a large spherical space containing a jelly-like substance and some wandering cells. Rudimentary tufts of glomerular capillaries and/or a mound-like swelling were present on the inner surface of the cyst wall, and the inner surface of the cysts was lined with an epithelium with pedicles. The epithelial cells were podocytes, whose surface structure was similar to that on the glomerular capillary in the normal renal corpuscle. The terminal foot processes were characteristically interdigitated not only on the glomerular capillaries, but also on the mound-like swelling and concave surface of the parietal portion of the cyst. A discrete, smooth-surfaced area was found on the side opposite to the glomerulus or swelling. This area was covered by squamous epithelial cells. At the peripheral zone of the smooth-surfaced area, elongated epithelial cells were demonstrated. Our findings indicate that the podocyte layer of the cyst corresponds to the internal leaflet of Bowman's capsule, and the squamous cell layer to the external leaflet. The mound-like swelling covered by podocytes is considered to represent a stage of possible evagination of the tufts of glomerular capillaries. There was no evidence of an opening of the urinary tubule in the cyst wall.
通过扫描电子显微镜和透射电子显微镜观察了猴肾皮质中的肾囊肿，以确定这些囊肿中上皮细胞的三维结构。囊肿由薄壁构成，薄壁界定了一个大的球形空间，其中含有一种胶状物质和一些游走细胞。囊肿壁的内表面存在肾小球毛细血管的原始小簇和/或丘状隆起，囊肿的内表面衬有带蒂的上皮。上皮细胞是足细胞，其表面结构与正常肾小体中肾小球毛细血管上的表面结构相似。终末足突不仅在肾小球毛细血管上，而且在囊肿壁的丘状隆起和壁层部分的凹面上典型地相互交错。在与肾小球或隆起相对的一侧发现了一个离散的、表面光滑的区域。该区域覆盖有鳞状上皮细胞。在光滑表面区域的周边区域，可见细长的上皮细胞。我们的研究结果表明，囊肿的足细胞层对应于鲍曼囊的内叶，鳞状细胞层对应于外叶。被足细胞覆盖的丘状隆起被认为代表了肾小球毛细血管小簇可能外翻的一个阶段。没有证据表明囊肿壁中有肾小管开口。
