镰状红细胞的镰状化不会改变磷脂不对称性。
Sickling of sickle erythrocytes does not alter phospholipid asymmetry.
作者信息
Raval P J, Allan D
出版信息
Biochem J. 1984 Oct 15;223(2):555-7. doi: 10.1042/bj2230555.
Abstract
Experiments in which phospholipase A2 has been used to examine the accessibility of phospholipids on the surface of sickled erythrocytes and of spectrin-free spicules derived from these cells have shown that accessibility is essentially unchanged compared with oxygenated sickle or normal erythrocytes. These results conflict with the claims of other workers that sickling is accompanied by loss of lipid asymmetry and that spectrin is important in maintaining the normal distribution of phospholipids in the erythrocyte membrane.
摘要
在一些实验中，磷脂酶A2被用于检测镰状红细胞表面以及源自这些细胞的无血影蛋白针状突起上磷脂的可及性，结果表明，与氧合镰状红细胞或正常红细胞相比，可及性基本未变。这些结果与其他研究人员的观点相矛盾，他们认为镰变伴随着脂质不对称性的丧失，并且血影蛋白对于维持红细胞膜中磷脂的正常分布很重要。
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