具有球系列结构的血型A糖脂（Ax），它是A1型红细胞所特有的：A1和A2区分的化学基础之一。
Blood group A glycolipid (Ax) with globo-series structure which is specific for blood group A1 erythrocytes: one of the chemical bases for A1 and A2 distinction.
作者信息
Clausen H, Watanabe K, Kannagi R, Levery S B, Nudelman E, Arao-Tomono Y, Hakomori S
出版信息
Biochem Biophys Res Commun. 1984 Oct 30;124(2):523-9. doi: 10.1016/0006-291x(84)91585-7.
A new blood group A-active glycolipid fraction, termed Ax, showing a chromatographic mobility between Aa and Ab was found in blood group A1 erythrocytes but not in A2 erythrocytes. Ax was identified by its conversion to "globo H" by alpha-N-acetylgalactosaminidase and by 1H-NMR spectroscopy as GalNAc alpha l----3[Fuc alpha l----2]Gal beta l----3GalNAc beta l----3Gal alpha l----4Gal beta l----4Glc beta l----lCer. Globo-H (Fuc alpha l----2Gal beta l----3GalNac beta l----3Gal alpha l----4Gal beta l----4Glc beta l----lCer) was found in blood group A, and O but not in A1 erythrocytes. Thus, one of the A1-specific determinants must be an A determinant carried by globo-series structure.
在A1血型红细胞中发现了一种新的具有A血型活性的糖脂组分，称为Ax，其在色谱中的迁移率介于Aa和Ab之间，而在A2血型红细胞中未发现。通过α-N-乙酰半乳糖胺酶将其转化为“球H”以及通过1H-NMR光谱鉴定，Ax为GalNAcα1----3[Fucα1----2]Galβ1----3GalNAcβ1----3Galα1----4Galβ1----4Glcβ1----1Cer。球H（Fucα1----2Galβ1----3GalNacβ1----3Galα1----4Galβ1----4Glcβ1----1Cer）存在于A血型和O血型中，但不存在于A1血型红细胞中。因此，A1特异性决定簇之一必定是由球系列结构携带的A决定簇。
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