Kaijima M, Cavareilho E A, de Carvalho L P, Dodd R, Rossier J, Naquet R
No To Shinkei. 1984 Aug;36(8):797-803.
The convulsant properties of methyl beta-carboline-3-carboxylate (beta-CCM), which is a homologue of a putative benzodiazepine receptor ligand in the mammalian central nervous system, were examined in cats. Subcutaneous injection of 0.5 mg/kg of the beta-CCM produced various degrees of myoclonic jerks always accompanied by cortical spike burst. Some autonomic symptoms such as tachypnea, hypersecretion of thick mucous saliva, vomiting and mydriasis were also presented. Subcutaneous injection of 1.0 mg/kg of the compound induced a generalized tonic-clonic convulsion. Injection of the same amount of the drug 1 hour later in the same cats failed to provoke a generalized seizure. Repeated injection of the same dose 3 hours later provoked a generalized seizure, but with a longer latency. However, repetition of the experiments 24 hours after or 10 days after the first injection consistently induced the same type of generalized seizure with the same latency as the first injections. These results support the suggestion that the pharmacological effect, especially the convulsive effect, of beta-CCM is dose-related, reversible and reproducible in the same cats and among different cats. Moreover, the postictal refractory period in this model of epilepsy may continue about for 3 hours.
β-咔啉-3-羧酸甲酯（β-CCM）是哺乳动物中枢神经系统中一种假定的苯二氮䓬受体配体的同系物，其惊厥特性在猫身上进行了研究。皮下注射0.5mg/kg的β-CCM会产生不同程度的肌阵挛性抽搐，总是伴有皮层棘波爆发。还出现了一些自主神经症状，如呼吸急促、浓稠黏液性唾液分泌过多、呕吐和瞳孔散大。皮下注射1.0mg/kg的该化合物会诱发全身性强直阵挛性惊厥。1小时后对同一只猫注射相同剂量的药物未能引发全身性癫痫发作。3小时后重复注射相同剂量会引发全身性癫痫发作，但潜伏期更长。然而，在首次注射后24小时或10天后重复进行实验，始终会诱发与首次注射相同类型的全身性癫痫发作，且潜伏期相同。这些结果支持了这样的观点，即β-CCM的药理作用，尤其是惊厥作用，在同一只猫和不同猫之间是剂量相关的、可逆的且可重复的。此外，在这个癫痫模型中，发作后的不应期可能持续约3小时。
