la Vecchia C, Franceschi S, Decarli A, Gallus G, Parazzini F, Merlo E
Br J Obstet Gynaecol. 1984 Nov;91(11):1149-55. doi: 10.1111/j.1471-0528.1984.tb15093.x.
Between 1970 and 1979, 103 women below 35 years of age with invasive cervical cancer were treated at the First Obstetrics and Gynaecology Clinic of the University of Milan. Nine patients were pregnant or less than 3 months postpartum. Estimated 10-year disease-free survival, determined by the life-table method, was 100% in stage IA (37 patients), 79% in stage IB (45 patients), 67% in stage II (15 patients), 0% in stages III (5 patients) and IV (1 patient). Prognosis was also strongly associated with lymph-node involvement, 10-year actuarial survival decreasing from 93% in lymph-node-negative to 44% in lymph-node-positive patients (P less than 0.001). The prognostic relevance of the clinical stage decreased after adjustment for lymph-node involvement, but the statistical significance of lymph-node involvement was unaffected when stage was allowed for. In the present series, the estimated 10-year disease-free survival was 80% in patients treated by radical hysterectomy compared with 62% in the group treated by total hysterectomy (stage IB to IV patients only); this difference, however, was not statistically significant when the data were adjusted for clinical stage (P = 0.10). None of the 20 patients with recurrent disease could be managed successfully.
1970年至1979年间，米兰大学第一妇产科诊所对103名35岁以下的浸润性宫颈癌女性进行了治疗。9名患者处于妊娠状态或产后不到3个月。采用寿命表法确定的估计10年无病生存率在IA期（37例患者）为100%，IB期（45例患者）为79%，II期（15例患者）为67%，III期（5例患者）和IV期（1例患者）为0%。预后还与淋巴结受累密切相关，10年精算生存率从淋巴结阴性患者的93%降至淋巴结阳性患者的44%（P<0.001）。在对淋巴结受累进行校正后，临床分期的预后相关性降低，但在考虑分期时，淋巴结受累的统计学意义不受影响。在本系列中，接受根治性子宫切除术的患者估计10年无病生存率为80%，而接受全子宫切除术的组（仅IB至IV期患者）为62%；然而，在对数据进行临床分期校正后，这种差异无统计学意义（P = 0.10）。20例复发患者均未能成功治疗。
