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[骨骼肌和心肌肌钙蛋白T与肌钙蛋白C相互作用的若干特性]

[Several peculiarities of the interaction of troponin T and troponin C of skeletal and cardiac muscle].

作者信息

Verin A D, Barskaia N V, Gusev N B

出版信息

Biokhimiia. 1984 Aug;49(8):1375-82.

PMID:6498238
Abstract

Using several independent methods, the interaction between troponin T and troponin C from skeletal and cardiac muscles was studied. It was found that troponin T and troponin C from skeletal muscles form a complex whose stability depends on Ca2+ concentration. Study of interactions between these troponin components demonstrated that both electrostatic and hydrophobic forces are involved in the complex formation. Cardiac troponin T and troponin C weakly interact with each other irrespective of experimental conditions. It was assumed that the weakening of interactions between the components of cardiac troponin is due to structural peculiarities of cardiac troponin T.

摘要

采用多种独立方法,对来自骨骼肌和心肌的肌钙蛋白T与肌钙蛋白C之间的相互作用进行了研究。结果发现,骨骼肌中的肌钙蛋白T和肌钙蛋白C形成一种复合物,其稳定性取决于Ca2+浓度。对这些肌钙蛋白成分之间相互作用的研究表明,复合物的形成涉及静电力和疏水力。无论实验条件如何,心肌肌钙蛋白T和肌钙蛋白C之间的相互作用都很弱。据推测,心肌肌钙蛋白各成分之间相互作用减弱是由于心肌肌钙蛋白T的结构特性所致。

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