Griffiths R W, Briggs J C
Br J Plast Surg. 1984 Oct;37(4):507-13. doi: 10.1016/0007-1226(84)90140-1.
284 patients with invasive cutaneous malignant melanoma and known maximal tumour thickness (MTT) were followed up for 10 to 16 years (or to earlier death) following conventional wide margin excision of the primary tumour. Of these 26 (9%) presented with clinical Stage II disease (enlarged regional lymph nodes). The 10 year disease free survival was 45% for clinical Stage I disease, with 5/26 patients with Stage II disease alive 10 years after tumour excision combined with lymph node dissection. Ninety per cent of first tumour recurrences (lymph node or local skin recurrence) occurred within 5 years of primary surgical treatment for clinical Stage I disease, whilst only 63% of deaths from melanoma occurred within this 5 year period. Although maximal tumour thickness is a valuable prognostic guide, cutaneous malignant melanoma remains an unpredictable disease.
284例患有浸润性皮肤恶性黑色素瘤且已知最大肿瘤厚度（MTT）的患者，在对原发肿瘤进行传统的宽切缘切除术后，随访了10至16年（或直至更早死亡）。其中26例（9%）表现为临床II期疾病（区域淋巴结肿大）。临床I期疾病的10年无病生存率为45%，26例II期疾病患者中有5例在肿瘤切除联合淋巴结清扫术后10年仍存活。临床I期疾病初次手术治疗后，90%的肿瘤复发（淋巴结或局部皮肤复发）发生在5年内，而黑色素瘤死亡病例中只有63%发生在这5年期间。尽管最大肿瘤厚度是一个有价值的预后指标，但皮肤恶性黑色素瘤仍然是一种不可预测的疾病。
