Chu N S
Brain Res. 1984 Oct 8;311(2):348-52. doi: 10.1016/0006-8993(84)90098-2.
The effects of ethanol on single midbrain raphe neurons were studied in the rat. For dorsal raphe neurons, only the units with rhythmic slow firing were consistently inhibited by ethanol. Those units often exhibited periodic cessation of spontaneous discharges in the initial responses, but later showed a dose-related slowing of discharge rates. Although median raphe neurons were also inhibited by ethanol, their responses consisted of an early tendency to fire more regularly, and then a decrease in spontaneous activity with bursting discharges. The data indicate that ethanol exerts different modes of inhibition on these two functionally different cell groups in the midbrain raphe complex.
在大鼠中研究了乙醇对单个中脑缝际核神经元的影响。对于背侧缝际核神经元，只有节律性慢放电的神经元持续受到乙醇抑制。这些神经元在初始反应中常常表现出自发放电的周期性停止，但随后显示出与剂量相关的放电率减慢。虽然中缝正中核神经元也受到乙醇抑制，但其反应包括早期放电更规律的趋势，然后是自发活动减少并伴有爆发性放电。数据表明，乙醇对中脑缝际核复合体中这两个功能不同的细胞群施加了不同的抑制模式。
