Bruyn G W
Cephalalgia. 1984 Sep;4(3):191-207. doi: 10.1046/j.1468-2982.1984.0403191.x.
To define more closely the clinical relationship between migraine and intracranial arteriovenous malformation (iAVM), the clinical features of 57 reported instances and of 7 personal cases were analysed. Migraine attacks symptomatic of AVM include: late onset, frequent absence of (familial) migraine history, diminution or even inversion of the usual sex-ratio in migraine, brevity of attacks, disruption of the usual sequence of attack symptoms and, finally, unusual or permanent neurologic deficit. An attempt has also been made to clarify the epidemiological relationship. The reported frequency of migraine in cases of AVM, and AVM in cases of migraine is reflected against an inquiry into the number of annually diagnosed cases of AVM in 20 Dutch neurological/neurosurgical centres, covering 12.10(6) inhabitants in 8 of the 11 provinces. The annual incidence of migraine is estimated at 1:3,500 population, that of diagnosed iAVM is 120, i.e. 1:100,000. Coincidental occurrence of the two conditions works out at 1:4 X 10(8) per year. The presented case series of 7 seen in 2 of the 20 centres strongly militates against such a chance hypothesis.
为了更确切地界定偏头痛与颅内动静脉畸形（iAVM）之间的临床关系，对57例已报道病例及7例个人病例的临床特征进行了分析。有AVM症状的偏头痛发作包括：发病较晚、常无（家族性）偏头痛病史、偏头痛中常见的性别比例降低甚至倒置、发作短暂、发作症状的通常顺序被打乱，以及最终出现异常或永久性神经功能缺损。还尝试阐明两者的流行病学关系。根据对荷兰20个神经科/神经外科中心每年诊断的AVM病例数的调查，反映了AVM病例中偏头痛的报道频率以及偏头痛病例中AVM的报道频率，这些中心覆盖了11个省中8个省的1210万居民。偏头痛的年发病率估计为每3500人中有1例，确诊的iAVM年发病率为120例，即每10万人中有1例。两种情况同时发生的概率为每年1:4×10⁸。在20个中心中的2个中心所见到的这7例病例系列有力地反驳了这种偶然假设。
