Toorchen D, Lindamood C, Swenberg J A, Topal M D
Carcinogenesis. 1984 Dec;5(12):1733-5. doi: 10.1093/carcin/5.12.1733.
O6-Methylguanine lesions in natural and synthetic DNAs were studied as substrates for the O6-methylguanine-DNA methyltransferase in vitro. The results indicate that O6-methylguanine is repaired by this protein when base paired to T as well as to C in double-stranded DNA. The results also indicate that O6-methylguanine is less subject to repair than previously reported when it is in single-stranded DNA and suggest that O6-methylguanine may not be repaired when it is at the 3' terminus.
研究了天然和合成DNA中的O6-甲基鸟嘌呤损伤作为体外O6-甲基鸟嘌呤-DNA甲基转移酶底物的情况。结果表明，在双链DNA中，当O6-甲基鸟嘌呤与T以及与C碱基配对时，该蛋白可对其进行修复。结果还表明，O6-甲基鸟嘌呤在单链DNA中时，其修复程度低于先前报道，并且提示O6-甲基鸟嘌呤在3'末端时可能无法被修复。
