Ishikawa T, Imamura T, Koiwaya Y, Tanaka K
Clin Cardiol. 1984 Nov;7(11):606-10. doi: 10.1002/clc.4960071110.
We describe two patients in whom spontaneous angina following acute myocardial infarction (postinfarction angina caused by coronary artery spasm) and worsening angina were successfully eliminated after clinical dosage of oral diltiazem, while marked sinus node suppression developed and temporary pacing was performed. The patients were females (one was 67 years and one was 64 years old), and had no history of sinus node dysfunction. The occurrence of the adverse effect was not during angina, and the intervals between the initiation of diltiazem and the occurrence were 6 days after 120 mg/day in one patient, and 4 h after a single administration of 60 mg in the other. Diltiazem is also efficacious in the elimination of unstable angina, however one should note that diltiazem may remarkably suppress not only atrioventricular node activity but also sinus node activity in some patients.
我们描述了两名患者，他们在急性心肌梗死后出现自发性心绞痛（由冠状动脉痉挛引起的梗死后心绞痛）且心绞痛加重，在口服临床剂量的地尔硫䓬后，自发性心绞痛成功消除，但出现了明显的窦房结抑制并进行了临时起搏。这两名患者均为女性（一名67岁，一名64岁），既往无窦房结功能障碍病史。不良反应并非在心绞痛发作期间出现，一名患者在每天服用120毫克地尔硫䓬6天后出现不良反应，另一名患者在单次服用60毫克4小时后出现不良反应。地尔硫䓬在消除不稳定型心绞痛方面也有效，然而，应注意地尔硫䓬在某些患者中不仅可能显著抑制房室结活动，还可能抑制窦房结活动。
