Masihi K N, Werner H, Lange W
Comp Immunol Microbiol Infect Dis. 1984;7(2):125-30. doi: 10.1016/0147-9571(84)90006-7.
Studies were carried out to determine the fate of virulent Toxoplasma gondii challenge in immune animals. Toxoplasma strains isolated from human, swine, rabbit and cat hosts were used for the primary immunization of mice. Brains were removed at various intervals after the challenge and subinoculated into normal mice. Prior immunization with one of the nine toxoplasma strains enabled the mice either to eliminate or harbour the challenge organisms without loss of virulence. The outcome of challenge infection was dependent on the parasite strain used for the immunization and the time interval between challenge and subinoculation. Mice immunized with strain KSU isolated from a cat eliminated repeatedly administered challenge from 80% of animals. Strain S 162 isolated from a swine eliminated similar challenge from only 20% of animals. The results indicate that the extent of protection against virulent T. gondii can vary widely and is related to the immunogenicity of the original immunizing strain.
开展了多项研究以确定免疫动物中强毒株弓形虫攻击后的情况。从人、猪、兔和猫宿主中分离出的弓形虫菌株用于小鼠的初次免疫。攻击后在不同时间间隔取出大脑并接种到正常小鼠体内。用九种弓形虫菌株之一进行预先免疫，可使小鼠要么清除要么携带攻击病原体而不失其毒力。攻击感染的结果取决于用于免疫的寄生虫菌株以及攻击与再次接种之间的时间间隔。用从猫分离出的KSU菌株免疫的小鼠，80%的动物能反复清除接种的攻击病原体。从猪分离出的S 162菌株仅能使20%的动物清除类似的攻击病原体。结果表明，针对强毒株弓形虫的保护程度差异很大，且与原始免疫菌株的免疫原性有关。
