[食管癌和胃癌中的垂体-肾上腺系统]
[The pituitary-adrenal system in cancer of the esophagus and stomach].
作者信息
Tarutinov V I, Ganul V L, Vinnitskiĭ V B, Pridatko O E
出版信息
Eksp Onkol. 1984;6(4):55-7.
Excretion of corticosteroids, levels of 11-OCS in blood plasma, tests with dexasone and clinical evaluation of the pituitary-adrenal system function were studied in 354 patients with carcinomas of the esophagus and proximal stomach division. Some degree of hypocorticism with a decrease in the 11-OCS level in blood plasma and lowered excretion of corticosteroids in the urine were found in 71% of patients. These variations are accompanied by lowered hypothalamus sensitivity to dexasone. Similar disturbances though less pronounced are determined in the precancerous states and in the remote periods after operation.
对354例食管癌和胃近端癌患者进行了皮质类固醇排泄、血浆11-氧皮质类固醇水平、地塞米松试验及垂体-肾上腺系统功能的临床评估。71%的患者存在一定程度的皮质功能减退，表现为血浆11-氧皮质类固醇水平降低和尿中皮质类固醇排泄减少。这些变化伴随着下丘脑对地塞米松敏感性降低。在癌前状态和术后远期也发现了类似但不太明显的紊乱。
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