Matsuda A, Kuzuya T
Endocrinol Jpn. 1984 Jun;31(3):335-41. doi: 10.1507/endocrj1954.31.335.
The family history of diabetes in parents and siblings was analyzed in relation to the age of onset and previous obesity in patients with non-insulin-dependent diabetes mellitus (NIDDM). The frequency of a positive family history of diabetes in parents was higher in patients with the onset of diabetes earlier than 40 years of age than in those who developed diabetes after 50 years of age (32% vs 12%, p less than 0.001). The frequency of a positive family history in siblings was about 20% and fairly constant in patients who became diabetic after 30 years. The prevalence of diabetes in siblings was higher in patients with diabetic parents than in those without diabetic parents (p less than 0.001). The higher frequency of diabetes in parents of young-onset patients remained significant even in a comparison of patient groups of similar ages (50-59 years) at the interview. Patients with definite obesity in the past had a significantly lower frequency of family history of diabetes in parents (p less than 0.001), and a lower prevalence of diabetes in their parents (p less than 0.001) and siblings (p less than 0.05) than did patients without obesity. The frequency of patients who had diabetic siblings did not differ between obese and lean groups. These data suggest that implications of the presence of diabetes in parents and in siblings are different in family history studies.(ABSTRACT TRUNCATED AT 250 WORDS)
对非胰岛素依赖型糖尿病（NIDDM）患者的父母及兄弟姐妹的糖尿病家族史进行了分析，分析内容涉及发病年龄及既往肥胖情况。糖尿病发病年龄早于40岁的患者，其父母有糖尿病家族史阳性的频率高于发病年龄在50岁之后的患者（32%对12%，p<0.001）。30岁之后患糖尿病的患者，其兄弟姐妹有糖尿病家族史阳性的频率约为20%，且相当稳定。有糖尿病父母的患者，其兄弟姐妹患糖尿病的患病率高于无糖尿病父母的患者（p<0.001）。即使在访谈时对年龄相近（50 - 59岁）的患者组进行比较，年轻发病患者的父母患糖尿病的较高频率仍然显著。过去有明确肥胖史的患者，其父母有糖尿病家族史的频率显著更低（p<0.001），其父母（p<0.001）及兄弟姐妹（p<0.05）患糖尿病的患病率也低于无肥胖史的患者。肥胖组和非肥胖组中，有糖尿病兄弟姐妹的患者频率无差异。这些数据表明，在家族史研究中，父母和兄弟姐妹患糖尿病的影响是不同的。（摘要截选至250词）
