Bodey G P, Ketchel S, Rodriguez V
J Infect Dis. 1978 May;137 Suppl:S139-S143. doi: 10.1093/infdis/137.supplement.s139.
The combination of carbenicillin plus cefamandole was administered to 88 patients with cancer during 116 evaluable episodes of fever. The overall response rate to carbenicillin plus cefamandole for the 116 episodes was 57%. There were 60 documented infections, of which 60% responded to this combination of antibiotics. The response rate was only 43% in patients with pneumonia. The etiologic agent was identified during 38 infections, of which 74% responded to carbenicillin plus cefamandole. Responses occurred less frequently in patients with neutropenia than in those without neutropenia and less frequently in patients whose infection was caused by organisms resistant to both antibiotics than in those with infection caused by organisms sensitive to one or both of the drugs. No side effects could be attributed to the antibiotic regimen.
在116次可评估的发热发作期间，对88例癌症患者使用了羧苄青霉素加头孢孟多的联合治疗。羧苄青霉素加头孢孟多对这116次发作的总体有效率为57%。有60例记录在案的感染，其中60%对这种抗生素联合治疗有反应。肺炎患者的有效率仅为43%。在38例感染中确定了病原体，其中74%对羧苄青霉素加头孢孟多有反应。中性粒细胞减少患者的反应比非中性粒细胞减少患者少，感染由对两种抗生素均耐药的病原体引起的患者的反应比感染由对一种或两种药物敏感的病原体引起的患者少。没有副作用可归因于抗生素治疗方案。
