Miselis R R, Hyde T M, Shapiro R E
Fed Proc. 1984 Dec;43(15):2969-71.
Lesions of the area postrema (AP) and immediately adjacent nucleus tractus solitarii cause a syndrome of permanent weight loss with little disruption to behavioral controls of body weight regulation. There is also a permanent polydipsia and elevated salt appetite, which appear to be secondary to deficits in renal conservation of water and sodium. Neuroanatomical studies indicate that the immediately adjacent solitary nucleus and AP are sites of termination of visceral afferents from abdominal organs and the destination and origin of distant central afferent and efferent connections.
最后区（AP）及紧邻的孤束核病变会导致永久性体重减轻综合征，对体重调节的行为控制几乎没有干扰。还会出现永久性烦渴和盐欲增加，这似乎是肾脏对水和钠的重吸收功能缺陷的继发表现。神经解剖学研究表明，紧邻的孤束核和最后区是来自腹部器官的内脏传入神经的终止部位，以及远距离中枢传入和传出连接的目的地和起源地。
