Di Giacomo V, Tedeschi A, Di Giacomo M
G Ital Cardiol. 1984 Aug;14(8):594-7.
In a patient with ischaemic heart disease chronic atrial flutter reverted to sinus rhythm during treatment with oral Verapamil, given at dosage of 240 mg once a day in order to prevent spontaneous angina. Such an unexpected event was accompanied by a remarkable sinus node depression and by a transient complete a-v block, that gradually subsides leaving a slight permanent a-v conduction delay. Either a higher bioavailability of the drug or an extremely increased sensitivity of the receptors can explain such a marked electrophysiological effect at a moderate drug dosage.
在一名缺血性心脏病患者中，慢性心房扑动在口服维拉帕米治疗期间恢复为窦性心律，维拉帕米的给药剂量为每日240毫克，用于预防自发性心绞痛。这一意外事件伴有显著的窦房结抑制和短暂的完全性房室传导阻滞，后者逐渐消退，仅留下轻微的永久性房室传导延迟。药物较高的生物利用度或受体敏感性的极度增加，均可解释在中等药物剂量下出现的这种显著电生理效应。
