Rannels D E, Burkhart L R, Watkins C A
Growth. 1984 Autumn;48(3):297-308.
The effects of unilateral pneumonectomy (PNX) on the net synthesis of right lung protein were investigated in vivo using three groups of rats with body weights (BW) ranging from 85 to 330 g. These data were compared to those from sham-operated and normal growing control animals. After PNX, both the 2-day lag prior to the compensatory increase in right lung mass (LW) and the subsequent rate of increase in LW and LW/BW ratio were independent of two-fold differences in the basal rate of lung growth. In all PNX groups, both right LW and LW/BW reached control values for both lungs, but in the older rats the time required for complete compensation was extended from 5 days to 12 days. The rate of net accumulation of right lung protein increased two-fold in the youngest PNX rats and 6 to 8-fold in the older animals, but when these changes were normalized to the protein content of the remaining tissue, the older rats appeared to respond to PNX less efficiently. Increased tissue levels of RNA and the resulting increased capacity of the lungs for protein synthesis could account for the accelerated rate of gain in right lung protein following PNX in both adult and young animals.
利用三组体重在85至330克之间的大鼠，在体内研究了单侧肺切除术（PNX）对右肺蛋白质净合成的影响。将这些数据与假手术组和正常生长的对照动物的数据进行比较。PNX后，右肺质量（LW）代偿性增加前的2天延迟以及随后LW和LW/BW比值的增加速率，均与肺生长基础速率的两倍差异无关。在所有PNX组中，右肺LW和LW/BW均达到了双侧肺的对照值，但在年龄较大的大鼠中，完全代偿所需的时间从5天延长至12天。最年幼的PNX大鼠右肺蛋白质的净积累速率增加了两倍，而年龄较大的动物增加了6至8倍，但当将这些变化与剩余组织的蛋白质含量进行归一化处理时，年龄较大的大鼠对PNX的反应似乎效率较低。RNA组织水平的增加以及由此导致的肺蛋白质合成能力的提高，可以解释成年和幼年动物PNX后右肺蛋白质增加速率的加快。
