Albert F, Bishop-Freudling G B, Vergin H
Fortschr Med. 1984 Nov 8;102(41):1064-6.
Two studies were conducted in neurosurgical patients to establish cerebrospinal fluid (CSF) and plasma levels of tetroxoprim (TXP) and sulphadiazine (SDZ) following the oral administration of co-tetroxazin in a standard dosage regimen. Both TXP (0,62-0,42 micrograms/ml) and SDZ (2,5-4,5 micrograms/ml) adequately penetrated into the CSF, resulting in concentrations above the MICs for most relevant pathogens. In relation to the respective plasma levels and under steady state conditions, CSF-availability is 37,5% for TXP and 31,8% for SDZ.
进行了两项针对神经外科患者的研究，以确定在标准给药方案下口服复方四氧嘧啶后脑脊液（CSF）和血浆中四氧普明（TXP）及磺胺嘧啶（SDZ）的水平。TXP（0.62 - 0.42微克/毫升）和SDZ（2.5 - 4.5微克/毫升）均能充分渗透至脑脊液中，致使浓度高于大多数相关病原体的最低抑菌浓度（MIC）。在稳态条件下，相对于各自的血浆水平，TXP的脑脊液可利用度为37.5%，SDZ为31.8%。
