Aun F, McIntosh T K, Lee A, Egdahl R H
Int Surg. 1984 Apr-Jun;69(2):101-5.
The circadian rhythms of plasma cortisol levels are studied extensively. Frequent sampling techniques are used to examine the effects of surgical trauma on the circadian pattern of plasma cortisol in man. Five patients were studied, 48 hours before and 48 hours after major surgery. The normal preoperative cortisol rhythms of these patients did not disappear after surgical trauma but they were significantly phase-shifted. In addition, the mean cortisol concentrations were significantly elevated and the intracircadian cycles suffered complex changes in the postoperative period.
血浆皮质醇水平的昼夜节律得到了广泛研究。采用频繁采样技术来检查手术创伤对人体血浆皮质醇昼夜模式的影响。对5名患者进行了研究，分别在大手术前48小时和术后48小时进行观察。这些患者术前正常的皮质醇节律在手术创伤后并未消失，但发生了显著的相位偏移。此外，术后平均皮质醇浓度显著升高，且昼夜内周期出现了复杂变化。
