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脆弱拟杆菌群对阿莫西林-克拉维酸的体外敏感性

The in-vitro susceptibility of the Bacteroides fragilis group to amoxycillin-clavulanic acid.

作者信息

Brown E M

出版信息

J Antimicrob Chemother. 1984 Oct;14(4):367-72. doi: 10.1093/jac/14.4.367.

DOI:10.1093/jac/14.4.367
PMID:6501130
Abstract

The susceptibility to amoxycillin-clavulanic acid of 150 strains belonging to the Bacteroides fragilis group was tested by both disc diffusion and agar dilution methods. On the basis of minimum inhibitory concentrations (MICs), at least 99% of the isolates were sensitive to this agent. However, problems encountered with the disc diffusion method suggest that at present it is unsatisfactory for assessing the in-vitro activity of amoxycillin-clavulanic acid against this group of organisms.

摘要

采用纸片扩散法和琼脂稀释法对150株脆弱拟杆菌属菌株进行了阿莫西林-克拉维酸敏感性检测。根据最低抑菌浓度(MIC),至少99%的分离株对该药物敏感。然而,纸片扩散法遇到的问题表明,目前它不能令人满意地评估阿莫西林-克拉维酸对这类微生物的体外活性。

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引用本文的文献

1
Comparative in vitro activities of amoxicillin-clavulanic acid and imipenem against anaerobic bacteria isolated from community hospitals.阿莫西林-克拉维酸与亚胺培南对社区医院分离出的厌氧菌的体外比较活性
Antimicrob Agents Chemother. 1986 Jan;29(1):158-60. doi: 10.1128/AAC.29.1.158.
2
Susceptibilities of species of the Bacteroides fragilis group to 10 antimicrobial agents.脆弱拟杆菌群各菌种对10种抗菌剂的敏感性。
Antimicrob Agents Chemother. 1990 Apr;34(4):671-3. doi: 10.1128/AAC.34.4.671.
3
Amoxicillin/clavulanic acid. An update of its antibacterial activity, pharmacokinetic properties and therapeutic use.
阿莫西林/克拉维酸:抗菌活性、药代动力学特性及治疗用途的最新进展
Drugs. 1990 Feb;39(2):264-307. doi: 10.2165/00003495-199039020-00008.