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Effect of antibiotic use on the incidence of cephalosporin resistance in two Australian hospitals.

作者信息

Benn R A, Kemp R J

出版信息

J Antimicrob Chemother. 1984 Sep;14 Suppl B:71-6. doi: 10.1093/jac/14.suppl_b.71.

DOI:10.1093/jac/14.suppl_b.71
PMID:6501136
Abstract

The incidence of resistance of Gram-negative bacteria to three generations of cephalosporins was surveyed in two large hospitals with widely differing rates of cephalosporin usage. Overall resistance (MIC greater than 5 mg/l) of Enterobacteriaceae to cefotaxime in the hospital using large amounts of cephalosporins was 4% compared with 0.7% in the other. Enterobacter species accounted for most resistant isolates and resistant Enterobacter cloacae replaced sensitive strains in four patients given cefotaxime in 1983. The distribution of species colonizing intensive care areas was similar in both hospitals with cephalosporin-resistant Pseudomonas aeruginosa and Acinetobacter calcoaceticus predominating.

摘要

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引用本文的文献

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Drugs. 1995 Sep;50(3):423-39. doi: 10.2165/00003495-199550030-00002.
2
Epidemiology of intestinal colonization by members of the family Enterobacteriaceae resistant to cefotaxime in a hematology-oncology unit.血液肿瘤病房中对头孢噻肟耐药的肠杆菌科细菌肠道定植的流行病学研究
Antimicrob Agents Chemother. 1986 Dec;30(6):945-7. doi: 10.1128/AAC.30.6.945.
3
Clinical importance of inducible beta-lactamases in gram-negative bacteria.
革兰氏阴性菌中诱导型β-内酰胺酶的临床重要性。
Eur J Clin Microbiol. 1987 Aug;6(4):435-8. doi: 10.1007/BF02013106.
4
Activity of cefepime against ceftazidime- and cefotaxime-resistant gram-negative bacteria and its relationship to beta-lactamase levels.头孢吡肟对头孢他啶和头孢噻肟耐药革兰阴性菌的活性及其与β-内酰胺酶水平的关系。
Antimicrob Agents Chemother. 1989 Apr;33(4):498-502. doi: 10.1128/AAC.33.4.498.