Caldwell J R, Frade P D, Reddy P J, Mayer J H, Kelly A R
J Chronic Dis. 1984;37(9-10):689-98. doi: 10.1016/0021-9681(84)90037-7.
Propranolol levels in plasma were studied in relation to dose prescribed in order to assess poor compliance with antihypertensive treatment. Fifty consecutive ambulatory patients (36-81 years) having hypertension, including 19 with azotemia, were investigated. Patient interviews using questionnaires and chart reviews were used to evaluate compliance. A composite Compliance Index was calculated for each patient. Individual oral doses of propranolol ranged from 20 to 160 mg. Subsequent plasma levels were determined by high performance liquid chromatography. Good correlation between last oral dose (mg) per body weight (kg) and log plasma propranolol levels were observed in patients whose compliance indices were above the mean for this sample (r = 0.74, p less than 0.01), when blood pressure control was satisfactory (r = 0.66) or excellent (r = 0.78), and when serum creatinines were greater than or equal to 1.4 (r = 0.76, p less than 0.001). Poor correlations between dose and propranolol levels suggest poor compliance with treatment.
为评估抗高血压治疗的依从性差，研究了血浆中普萘洛尔水平与规定剂量的关系。对50例连续的门诊高血压患者（年龄36 - 81岁）进行了调查，其中包括19例氮质血症患者。通过问卷调查和病历审查对患者进行访谈以评估依从性。为每位患者计算综合依从性指数。普萘洛尔的个体口服剂量范围为20至160毫克。随后通过高效液相色谱法测定血浆水平。在依从性指数高于该样本平均值的患者中，观察到每体重（kg）的最后口服剂量（mg）与血浆普萘洛尔水平的对数之间存在良好的相关性（r = 0.74，p < 0.01），当血压控制良好（r = 0.66）或极佳（r = 0.78）时，以及当血清肌酐大于或等于1.4时（r = 0.76，p < 0.001）。剂量与普萘洛尔水平之间的相关性差表明治疗依从性差。
