J Am Coll Cardiol. 1984 Dec;4(6):1135-47. doi: 10.1016/s0735-1097(84)80132-1.
The prognostic significance of blood pressure elevation and its associated characteristics in patients recovered from myocardial infarction was studied in the placebo group (n = 2,789) of the Coronary Drug Project. Age, relative body weight, heart rate and ST depression on the electrocardiogram were important positive correlates of hypertension measured at baseline. The relation of uric acid and elevated plasma glucose levels to increased blood pressure could be partially explained as side effects of thiazide diuretic therapy. A "high normal" baseline blood pressure best predicted the development of hypertension among survivors of myocardial infarction. Both combined systolic and diastolic hypertension and isolated systolic hypertension were adverse prognostic factors. Changes in blood pressure, including the prognostic implications of a decrease in pressure, were also analyzed in the subset of patients who sustained a recurrent nonfatal myocardial infarction. Decreases in systolic (mean 7.9 mm Hg) and diastolic (mean 3.6 mm Hg) blood pressure were sustained in this subset. Patients whose blood pressure decreased after recurrent myocardial infarction tended to have higher mortality rates than those of comparable patients whose blood pressure increased or remained unchanged.
在冠状动脉药物项目的安慰剂组（n = 2789）中，研究了心肌梗死康复患者血压升高及其相关特征的预后意义。年龄、相对体重、心率和心电图上的ST段压低是基线时测量的高血压的重要正相关因素。尿酸和血糖水平升高与血压升高之间的关系可部分解释为噻嗪类利尿剂治疗的副作用。“高正常”基线血压最能预测心肌梗死幸存者中高血压的发生。收缩压和舒张压联合升高以及单纯收缩期高血压均为不良预后因素。在发生复发性非致命性心肌梗死的患者亚组中，还分析了血压变化，包括血压下降的预后意义。该亚组患者的收缩压（平均7.9 mmHg）和舒张压（平均3.6 mmHg）持续下降。复发性心肌梗死后血压下降的患者比血压升高或不变的类似患者死亡率更高。
