四名兄弟姐妹在接触苯妥英和扑米酮后出现了相似的畸形。

Four siblings with similar malformations after exposure to phenytoin and primidone.

作者信息

Krauss C M, Holmes L B, VanLang Q, Keith D A

出版信息

J Pediatr. 1984 Nov;105(5):750-5. doi: 10.1016/s0022-3476(84)80295-4.

Abstract

Four siblings exposed to phenytoin or primidone or both in utero are reported. Each has craniofacial features consistent with fetal hydantoin syndrome. Two of the siblings were exposed to primidone alone, indicating that phenytoin and primidone may have similar teratogenic effects.

摘要

据报道，有4名兄弟姐妹在子宫内接触过苯妥英或扑米酮或两者。每个人都有与胎儿乙内酰脲综合征相符的颅面特征。其中两名兄弟姐妹仅接触过扑米酮，这表明苯妥英和扑米酮可能具有相似的致畸作用。