Houin G, Barre J, Tillement J P
J Pharm Sci. 1984 Oct;73(10):1450-3. doi: 10.1002/jps.2600731033.
A study was designed to estimate the absolute bioavailability of alizapride after intramuscular injection, oral administration as a solution or a tablet, and rectal administration as a suppository compared with that after intravenous injection. A balanced incomplete block-design trial was adopted. The intramuscular injection and the tablet administration showed identical results with those of the intravenous injection. On the contrary, the oral solution and the rectal suppository dosage forms gave lower absorption values, i.e., 75 and 61% of the dose administered was absorbed, respectively.
一项研究旨在评估阿立必利在肌内注射、口服溶液或片剂以及直肠给药栓剂后与静脉注射后的绝对生物利用度。采用了平衡不完全区组设计试验。肌内注射和片剂给药的结果与静脉注射相同。相反，口服溶液和直肠栓剂剂型的吸收值较低，即分别吸收了给药剂量的75%和61%。
