Sawada M, McAdoo D J, Ichinose M, Price C H
Jpn J Physiol. 1984;34(4):747-67. doi: 10.2170/jjphysiol.34.747.
Firing neuron R14 in the Aplysia parietovisceral ganglion enhances the force of stimulated contractions and causes rhythmic contractions rather than individual contractions in response to a single stimulation of the anterior aorta of Aplysia. Bath application of 1.0 mM glycine to the artery causes a small depolarization, rhythmic contractions and enhances the force of individual, neurally induced contractions of the anterior aorta. These observations suggest that the physiological role of the innervation of the anterior aorta by R14 is to convert the mode of contraction of the anterior aorta from direct neural control to a myogenic mode. R14 activity does not produce classical junction potentials and inotophoretically applied glycine does not produce detectable potential changes in the anterior aorta muscle fibers. Glycine increases the force and frequency of Aplysia heart beat, and blood pressure. Glycine causes release of preloaded Ca2+ from the ventricle of the Aplysia heart, implying that glycine causes intracellular release of Ca2+. The similarity of the actions of glycine and electrical activity in R14 extend previous evidence that R14 may utilize glycine to modulate the contractility of Aplysia circulatory muscle.
海兔腹脏神经节中的神经元R14放电可增强刺激引起的收缩力，并在对海兔前主动脉进行单次刺激时引发节律性收缩而非单个收缩。将1.0 mM甘氨酸浴应用于动脉会引起轻微去极化、节律性收缩，并增强前主动脉单个神经诱导收缩的力量。这些观察结果表明，R14对前主动脉的神经支配的生理作用是将前主动脉的收缩模式从直接神经控制转变为肌源性模式。R14的活动不会产生经典的接头电位，且通过离子电泳施加的甘氨酸在前主动脉肌纤维中不会产生可检测到的电位变化。甘氨酸会增加海兔心跳的力量和频率以及血压。甘氨酸会导致海兔心脏心室中预加载的Ca2+释放，这意味着甘氨酸会引起细胞内Ca2+释放。甘氨酸与R14电活动作用的相似性扩展了先前的证据，即R14可能利用甘氨酸来调节海兔循环肌肉的收缩性。
