Atanacković D, Zupan G, Simonić A
Jugosl Ginekol Opstet. 1984 May-Aug;24(3-4):51-3.
Influence of histamine and histaminergic H1 blockers (antazoline, promethazine) and H2 blockers (cimetidine, ranitidine) on isometric contraction of helically cut strips of human umbilical vein was examined. Histamine produced dose-related contraction of the vein strip, while histaminergic H1 and H2 blockers did not changed the tonus of the vein. The contractile activity of histamine was not influenced by cimetidine or ranitidine, while antazoline and promethazine antagonized mentioned activity of histamine completely. We suppose that histamine exerts contractile effect of human umbilical vein by acting on H1 receptors while H2 receptors are not involved in the mentioned activity of histamine.
研究了组胺、组胺能H1受体阻滞剂（安他唑啉、异丙嗪）和H2受体阻滞剂（西咪替丁、雷尼替丁）对人脐静脉螺旋条等长收缩的影响。组胺使静脉条产生剂量相关的收缩，而组胺能H1和H2受体阻滞剂未改变静脉的张力。组胺的收缩活性不受西咪替丁或雷尼替丁的影响，而安他唑啉和异丙嗪完全拮抗组胺的上述活性。我们推测组胺通过作用于H1受体发挥对人脐静脉的收缩作用，而H2受体不参与组胺的上述活性。
