长期抗惊厥治疗对人体肝脏超微结构的影响。

Influence of long-term anticonvulsant treatment on liver ultrastructure in man.

作者信息

Pamperl H, Gradner W, Fridrich L, Pointner H, Denk H

出版信息

Liver. 1984 Oct;4(5):294-300. doi: 10.1111/j.1600-0676.1984.tb00941.x.

DOI:10.1111/j.1600-0676.1984.tb00941.x

Abstract

In 35 patients on long-term anticonvulsant treatment (7-35 years, means = 19.6 years), various liver enzymes were measured. In 32 cases (91.4%), elevated levels of serum-gamma-glutamyl-transpeptidase (GGT) were found. Liver biopsy was performed in five of 13 patients with GGT levels of greater than 60 U/l (75-257, means = 123 U/l). Light microscopy showed a minimal steatosis and fine granular appearance of hepatocytes in two cases, and a slight portal fibrosis in one case. Two cases showed an unremarkable histology. Electron microscopy revealed signs of enzyme induction as overall swelling of the smooth endoplasmic reticulum and additionally a dilatation of the rough endoplasmic reticulum in all five specimens. No signs of liver damage or disturbance of liver function could be observed.

摘要

对35例接受长期抗惊厥治疗的患者（7至35岁，平均19.6岁）进行了多种肝酶检测。在32例患者（91.4%）中，发现血清γ-谷氨酰转肽酶（GGT）水平升高。13例GGT水平高于60 U/l（75至257，平均123 U/l）的患者中有5例进行了肝活检。光学显微镜检查显示，2例有轻微脂肪变性和肝细胞细颗粒外观，1例有轻微门脉纤维化。2例组织学检查无异常。电子显微镜检查显示，所有5个标本均有酶诱导迹象，即滑面内质网整体肿胀，粗面内质网扩张。未观察到肝损伤或肝功能紊乱的迹象。