Uchino J, Hata Y, Kasai Y
J Pediatr Surg. 1978 Apr;13(2):167-72. doi: 10.1016/s0022-3468(78)80013-x.
This is a review of the findings in 10 cases of stage IVS neuroblastoma, that have been observed in the First Surgical Department of Hokkaido University Hospital. The patients under the age of 1 yr in stage IVS neuroblastoma have a favorable prognosis; the survival rate was 70%. The regressions were histologically confirmed as maturation of the neuroblastoma cells to ganglioma cells. The lymphocyte counts and T-cell function were well maintained in the surviving patients but both were markedly reduced in the patients who later died. The treatment should be conservative so that immune mechanisms are not inhibited and should be withheld until respiratory failure or progressive signs toward stage IV are identified.
这是对北海道大学医院第一外科观察到的10例IV-S期神经母细胞瘤病例研究结果的综述。IV-S期神经母细胞瘤1岁以下患者预后良好，生存率为70%。组织学证实肿瘤消退表现为神经母细胞瘤细胞成熟为神经节瘤细胞。存活患者的淋巴细胞计数和T细胞功能维持良好，但后期死亡患者这两项指标均显著降低。治疗应采取保守方式，以免抑制免疫机制，且在出现呼吸衰竭或向IV期进展的迹象之前应暂缓治疗。
