Mussa A, Giugno G, Bertoldi G C
Minerva Med. 1984 Oct 20;75(40):2369-71.
The effect of Flunitrazepam on the human lower oesophageal sphincter is evaluated. Pressure in the LOS and GOR using the Acid Reflux Test was evaluated in 22 surgical cases at rest (after ingestions of a placebo and Flunitrazepam). The results obtained indicate that the LOS pressure variations induced by flunitrazepam significantly increase the probability of GOR.
评估了氟硝西泮对人体下食管括约肌的作用。在22例手术病例中,于静息状态下(摄入安慰剂和氟硝西泮后),使用酸反流试验评估下食管括约肌(LOS)压力和胃食管反流(GOR)情况。所获结果表明,氟硝西泮引起的LOS压力变化显著增加了胃食管反流的可能性。