Zeigler H P, Jacquin M F, Miller M G
Neurosci Biobehav Rev. 1984 Fall;8(3):415-23. doi: 10.1016/0149-7634(84)90061-7.
Selective section of trigeminal orosensory nerves was carried out to assess the contributions of trigeminal orosensation to the control of food and water intake in the rat. Trigeminal orosensory deafferentation reduces a responsiveness to food and water, disrupts jaw-opening and tongue protrusion reflexes mediating eating and drinking, impairs dietary self-selection and reduces the level of long-term body weight regulation. The magnitude of the feeding behavior deficits is a joint function of the extent of the denervation and the sensory properties of the diet, and recovery takes place along a palatability gradient. Analysis of feeding and drinking patterns and of learned instrumental behaviors indicates that deafferentation reduces the probability of initiating a feeding or drinking bout and profoundly disrupts performance of operant responses reinforced with food or water. We conclude that the trigeminal system contributes to both the sensorimotor and motivational control of ingestive behavior. Its motivational contributions differ in both kind and magnitude from those of the gustatory system.
为评估三叉神经口腔感觉神经对大鼠食物和水摄入控制的作用，进行了三叉神经口腔感觉神经的选择性切断。三叉神经口腔感觉传入神经切断会降低对食物和水的反应性，破坏介导进食和饮水的张口和伸舌反射，损害饮食自我选择，并降低长期体重调节水平。摄食行为缺陷的严重程度是去神经程度和饮食感官特性的联合作用，恢复沿着适口性梯度发生。对进食和饮水模式以及习得的工具性动作的分析表明，去传入神经会降低开始进食或饮水回合的概率，并严重破坏以食物或水强化的操作性反应的表现。我们得出结论，三叉神经系统对摄食行为的感觉运动和动机控制都有贡献。其动机贡献在种类和程度上与味觉系统的贡献不同。
