Szabó J, Herczeg J, Thurzó L, Szemere G
Obstet Gynecol. 1984 Dec;64(6):807-10.
Chorionic villi were sampled by transcervical aspiration after ultrasonic localization of the chorion frondosum. Sampling was successful in 82 of 98 women. Subsequent karyotyping of the chorionic material was done by the modified Evans method. Mitoses of reasonable quality were obtained providing an easy cytogenetic diagnosis from human cytotrophoblast. A second trimester chorionic plate biopsy and direct karyotyping in case of severe oligohydramnios and malformed fetus revealing numerical (45, XO) chromosomal abnormality is also reported.
在超声定位绒毛叶后，经宫颈抽吸获取绒毛样本。98名女性中有82名采样成功。随后采用改良的埃文斯方法对绒毛材料进行核型分析。获得了质量良好的有丝分裂图像，从而能够从人细胞滋养层进行简易的细胞遗传学诊断。本文还报道了在孕中期进行绒毛板活检以及在出现严重羊水过少和胎儿畸形且核型分析显示数目异常（45，XO）染色体异常的情况下进行直接核型分析的情况。
