De Blaey C J, Varkevisser F A, Kalk A
Pharm Weekbl Sci. 1984 Oct 19;6(5):203-8. doi: 10.1007/BF01999943.
The physical state, melting behaviour and release rate of aminophylline suppositories were studied during storage. The fraction of non-crystallized fat, assessed by pulse NMR, varies between different vehicles. At room temperature several vehicles do not seem to be completely crystalline. Aging, as observed in prolonged melting time and a reduced release rate, is not expressed in a drastic reduction of the fraction of non-crystallized fat, as observed by NMR. On the contrary the mobility of the protons in the non-crystallized state is likely to offer a more promising tool to monitor aging.
在储存期间对氨茶碱栓剂的物理状态、熔化行为和释放速率进行了研究。通过脉冲核磁共振评估的未结晶脂肪部分在不同载体之间有所不同。在室温下，几种载体似乎并非完全结晶。通过延长熔化时间和降低释放速率所观察到的老化现象，并没有像核磁共振所观察到的那样表现为未结晶脂肪部分的急剧减少。相反，未结晶状态下质子的流动性可能为监测老化提供一个更有前景的工具。
