Alterations in the dopaminergic system and behaviour in rats reared on iodine-deficient diets.

Male rats raised on an iodine-deficient diet were found to be retarded in growth rate, to have lowered body temperature, and to have poorer memory retention of a passive avoidance task than rats raised on a similar diet but with adequate iodine concentration. In addition, the iodine deficient rats showed increased locomotor activity and sniffing frequency after the dopamine agonist, apomorphine; while their operant performance was inhibited to a greater degree after apomorphine. However, the hypothermic effects of apomorphine were comparable in both iodine-deficient and normal rats. At sacrifice the iodine-deficient rats were found to have significantly depressed thyroxine levels (less than 10% of normal), significantly elevated TSH levels (greater than 700% of normal), and a significantly greater concentration of dopamine receptors in the striatum (28% increase). Thus, rats raised on iodine-deficient diets have considerable behavioural and physiological alterations, including an increased concentration of dopamine receptors.