Lograno M D, Daniele E, Camerino D C
Pharmacol Res Commun. 1984 Oct;16(10):999-1008. doi: 10.1016/s0031-6989(84)80064-8.
Sympathetic amines were tested on isolated trachea of guinea pig at physiological (7.4) and acid (6.6) pH. At physiological pH noradrenaline and phenylephrine relaxed the spontaneous tone of the tracheal muscle preparation; when propranolol was previously added to the organ bath solution, noradrenaline and phenylephrine didn't affect the tracheal muscle tone. Tested at acid pH (6.6), noradrenaline and phenylephrine still relaxed tracheal muscle preparations, but in the presence of propranolol these drugs increased the muscle tone. The spasmogenic effect produced by noradrenaline and phenylephrine after beta-receptor blockade by propranolol, was completely abolished by phentolamine. The present results suggest that acidosis could alter the responsiveness of both alpha- and beta-adrenoceptors in the tracheal muscle of guinea pig.
在生理pH值（7.4）和酸性pH值（6.6）条件下，对豚鼠离体气管进行了交感胺测试。在生理pH值时，去甲肾上腺素和苯肾上腺素可使气管肌肉标本的自发张力松弛；当预先向器官浴液中加入普萘洛尔时，去甲肾上腺素和苯肾上腺素不影响气管肌肉张力。在酸性pH值（6.6）下测试时，去甲肾上腺素和苯肾上腺素仍可使气管肌肉标本松弛，但在普萘洛尔存在的情况下，这些药物会增加肌肉张力。普萘洛尔阻断β受体后，去甲肾上腺素和苯肾上腺素产生的致痉作用被酚妥拉明完全消除。目前的结果表明，酸中毒可能会改变豚鼠气管肌肉中α和β肾上腺素能受体的反应性。
