Della Corte L, Sgaragli G P
Pharmacol Res Commun. 1984 Feb;16(2):207-13. doi: 10.1016/s0031-6989(84)80096-x.
The pattern of distribution of chlorimipramine (CI) and of its demethyl-derivative (DMCI) in different organs (lung, liver, kidney, heart and spleen) 24 h after a single dose of CI was examined and related to the amounts of the most representative classes of lipids present in tissues. The findings here reported show that lung and liver have the highest capacity to accumulate CI while DMCI was preferentially accumulated by lung, spleen and kidney. The capacity of the examined tissues to accumulate CI and DMCI did not relate to their lipid content.
在单次服用氯米帕明（CI）24小时后，研究了氯米帕明及其去甲基衍生物（DMCI）在不同器官（肺、肝、肾、心和脾）中的分布模式，并将其与组织中最具代表性的脂质种类的含量相关联。此处报告的研究结果表明，肺和肝积累CI的能力最强，而DMCI则优先在肺、脾和肾中积累。所检测组织积累CI和DMCI的能力与其脂质含量无关。
